{"id":5310,"date":"2024-10-10T16:02:27","date_gmt":"2024-10-10T14:02:27","guid":{"rendered":"https:\/\/www.ehc.eu\/bleeding-disorder\/deficit-en-facteur-ii-prothrombine\/"},"modified":"2025-12-23T09:58:41","modified_gmt":"2025-12-23T08:58:41","slug":"deficit-en-facteur-ii-prothrombine","status":"publish","type":"bleeding-disorder","link":"https:\/\/www.ehc.eu\/fr\/bleeding-disorder\/deficit-en-facteur-ii-prothrombine\/","title":{"rendered":"D\u00e9ficit en facteur II (prothrombine)"},"content":{"rendered":"<!-- hero -->\t<section   class=\"subpage-hero bg-red text-white\">\n\t\t<div class=\"container\">\n\t\t\t<div class=\"relative z-10\">\n\t\t\t\t<div class=\"pt-16 lg:pt-24 pb-24 lg:pb-32\">\n\t\t\t\t\t<div class=\"row justify-between gap-10 lg:gap-0 mt-10 text-center lg:text-left\">\n\t\t\t\t\t\t<div class=\"w-full lg:w-6\/12 lg:self-center\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title h2\" data-scroll data-fade-up>\n\t\t\t\t\t\t\t\t\t<p class=\"text-[115%]\">D\u00e9ficit en facteur II (prothrombine)<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"content mt-14 lg:mt-20\" data-scroll data-fade-up data-delay-02>\n\t\t\t\t\t\t\t\t\t<p>Trouble h\u00e9r\u00e9ditaire rare de la coagulation d\u00fb \u00e0 une activit\u00e9 r\u00e9duite du facteur II (FII, prothrombine) et caract\u00e9ris\u00e9 par des sympt\u00f4mes de saignement des muqueuses et des tissus mous.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<figure class=\"absolute size-[82.8rem] bottom-[-30%] right-[-5%] image-contain opacity-20 skip-lazy\" data-parallax>\n\t                <img decoding=\"async\" loading=\"eager\" src=\"https:\/\/etngbd86n6b.exactdn.com\/wp-content\/themes\/cbd\/img\/content-logo-colorfull.svg\" alt=\"content-logo-colorfull\">\n\t            <\/figure>\n\t\t\t\t\t\t<\/section>\n<!-- overview -->\t<section   class=\"s-overlay-img s-padding\">\n\t\t<div class=\"container\">\n\t\t\t<div class=\"row w-full lg:flex-row-reverse justify-between text-center lg:text-left relative z-10\">\n\t\t\t\t\t\t\t\t\t<div class=\"w-full lg:w-6\/12 min-h-full\">\n\t\t\t\t\t\t<div class=\"w-full h-[35rem] lg:h-[25vmax] min-h-full relative overflow-hidden radius-20\">\n\t\t\t\t\t\t\t<figure class=\"absolute top-0 left-0 size-full radius-20\" data-img-animation>\n\t\t\t\t\t\t\t\t<img width=\"410\" height=\"491\" src=\"https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7.jpg?strip=all&amp;sharp=1\" class=\"attachment-large size-large\" alt=\"\" decoding=\"async\" loading=\"lazy\" srcset=\"https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7.jpg?strip=all&amp;sharp=1 410w, https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7-251x300.jpg?strip=all&amp;sharp=1 251w, https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7.jpg?strip=all&amp;sharp=1&amp;w=82 82w, https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7.jpg?strip=all&amp;sharp=1&amp;w=164 164w, https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7.jpg?strip=all&amp;sharp=1&amp;w=328 328w\" sizes=\"auto, (max-width: 410px) 100vw, 410px\" \/>\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"w-full lg:w-6\/12 lg:py-10\">\n\t\t\t\t\t<div class=\"lg:w-[120%] bg-white py-12 px-0 lg:py-24 lg:px-24 relative radius-20 z-10\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"content mt-8\" data-scroll data-fade-up>\n\t\t\t\t\t\t\t\t<p><strong>\u00c9pid\u00e9miologie<br \/>\n<\/strong>Le d\u00e9ficit en facteur II est le plus rare des d\u00e9ficits en facteur de coagulation. La pr\u00e9valence des formes homozygotes est estim\u00e9e \u00e0 1\/2 000 000. Les deux sexes sont \u00e9galement touch\u00e9s.  <\/p>\n<p><strong>Description clinique<br \/>\n<\/strong>Le d\u00e9ficit cong\u00e9nital en FII peut se manifester \u00e0 tout \u00e2ge, les formes graves de la maladie se manifestant t\u00f4t dans la vie. Les signes cliniques courants sont l&rsquo;\u00e9pistaxis, la m\u00e9norragie, les saignements de la cavit\u00e9 buccale, les saignements des muqueuses, les saignements des tissus mous, l&rsquo;h\u00e9marthrose, les ecchymoses faciles et les saignements prolong\u00e9s apr\u00e8s l&rsquo;extraction d&rsquo;une dent, un traumatisme ou une intervention chirurgicale. Les formes graves peuvent pr\u00e9senter une h\u00e9morragie intracr\u00e2nienne. La gravit\u00e9 des manifestations h\u00e9morragiques est en corr\u00e9lation avec les taux de FII. Des manifestations thromboemboliques ont \u00e9t\u00e9 d\u00e9crites en cas de dysprothrombin\u00e9mie.    <\/p>\n<p><strong>\u00c9tiologie<br \/>\n<\/strong>Le d\u00e9ficit h\u00e9r\u00e9ditaire en FII est d\u00fb \u00e0 des mutations du g\u00e8ne <i>F2<\/i> (11p11-q12) codant pour la prothrombine.<\/p>\n<p><strong>M\u00e9thodes de diagnostic<br \/>\n<\/strong>Le diagnostic est bas\u00e9 sur l&rsquo;allongement des temps de prothrombine et de thromboplastine partielle activ\u00e9e (TP, aPTT) et sur une faible activit\u00e9 coagulante FII mesur\u00e9e \u00e0 l&rsquo;aide d&rsquo;un test bas\u00e9 sur le TP. Des tests mol\u00e9culaires sont disponibles, mais ne sont pas n\u00e9cessaires au diagnostic. <\/p>\n<p><strong>Diagnostic diff\u00e9rentiel<br \/>\n<\/strong>Les diagnostics diff\u00e9rentiels incluent les d\u00e9ficiences en facteurs V, VII, X, VIII, IX, XI, XIII ou les d\u00e9ficiences acquises en FII (lupus anticoagulant).<\/p>\n<p><strong>Diagnostic pr\u00e9natal<br \/>\n<\/strong>Un diagnostic pr\u00e9natal est disponible pour les formes les plus graves.<\/p>\n<p><strong>Conseil g\u00e9n\u00e9tique<br \/>\n<\/strong>La transmission est autosomique r\u00e9cessive. Un conseil g\u00e9n\u00e9tique devrait \u00eatre propos\u00e9 aux couples \u00e0 risque (les deux individus sont porteurs d&rsquo;une mutation causant la maladie), les informant du risque de 25 % d&rsquo;avoir un enfant atteint \u00e0 chaque grossesse. <\/p>\n<p><em>L&rsquo;information est tir\u00e9e du site web Orpha.net<\/em><\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/section>\n<!-- features --><section   class=\"s-padding-bottom\">\n\t<div class=\"container\">\n\t\t\t\t\t<div class=\"grid sm:grid-cols-2 lg:grid-cols-4 gap-10 text-center lg:text-left\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div data-scroll data-fade-left data-delay-0>\n\t\t\t\t\t\t<div class=\"flex flex-col gap-7 min-h-full px-10 lg:px-16 py-14 lg:py-24 text-white bg-blue radius-20 z-10\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title h4\">\n\t\t\t\t\t\t\t\t\t<p>D\u00e9ficit cong\u00e9nital en facteur II<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"w-full\">\n\t\t\t\t\t\t\t\t\t\t\t<p>Pr\u00e9valence<\/p>\n\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"h5\">\n\t\t\t\t\t\t\t\t\t\t\t<p>  &lt;1 \/ 1 000 000<\/p>\n\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section><!-- overview -->\t<section   class=\"s-overlay-img s-padding-medium\">\n\t\t<div class=\"container\">\n\t\t\t<div class=\"row w-full lg:flex-row justify-between text-center lg:text-left relative z-10\">\n\t\t\t\t\t\t\t\t\t<div class=\"w-full lg:w-4\/12 min-h-full\">\n\t\t\t\t\t\t<div class=\"w-full lg:w-[115%] h-[35rem] lg:h-[25vmax] min-h-full relative overflow-hidden radius-20\">\n\t\t\t\t\t\t\t<figure class=\"absolute top-0 left-0 size-full radius-20\" data-img-animation>\n\t\t\t\t\t\t\t\t<img width=\"410\" height=\"491\" src=\"https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7.jpg?strip=all&amp;sharp=1\" class=\"attachment-large size-large\" alt=\"\" decoding=\"async\" loading=\"lazy\" srcset=\"https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7.jpg?strip=all&amp;sharp=1 410w, https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7-251x300.jpg?strip=all&amp;sharp=1 251w, https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7.jpg?strip=all&amp;sharp=1&amp;w=82 82w, https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7.jpg?strip=all&amp;sharp=1&amp;w=164 164w, https:\/\/etngbd86n6b.exactdn.com\/wp-content\/uploads\/2024\/10\/image-7.jpg?strip=all&amp;sharp=1&amp;w=328 328w\" sizes=\"auto, (max-width: 410px) 100vw, 410px\" \/>\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div class=\"w-full lg:w-8\/12 lg:py-10\">\n\t\t\t\t\t<div class=\"bg-white py-12 px-0 lg:py-24 lg:px-32 relative radius-20 z-10\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"title h4\" data-scroll data-fade-up>\n\t\t\t\t\t\t\t\t<p>Prise en charge et traitement<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"content mt-8\" data-scroll data-fade-up>\n\t\t\t\t\t\t\t\t<p>Les concentr\u00e9s de complexe prothrombique (CCP) ou le plasma frais congel\u00e9 (si les CCP ne sont pas disponibles) sont g\u00e9n\u00e9ralement utilis\u00e9s pour traiter les \u00e9pisodes h\u00e9morragiques.<\/p>\n<p><strong>Pronostic<\/strong><br \/>\nLe pronostic est bon avec un diagnostic pr\u00e9coce et un traitement ad\u00e9quat.<\/p>\n<p><em>Les informations sont extraites du site web Orpha.net.<\/em><\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/section>\n<!-- newsletter -->","protected":false},"template":"","meta":{"_acf_changed":false},"bleeding-disorder_cat":[],"class_list":["post-5310","bleeding-disorder","type-bleeding-disorder","status-publish","hentry"],"acf":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.ehc.eu\/fr\/wp-json\/wp\/v2\/bleeding-disorder\/5310","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ehc.eu\/fr\/wp-json\/wp\/v2\/bleeding-disorder"}],"about":[{"href":"https:\/\/www.ehc.eu\/fr\/wp-json\/wp\/v2\/types\/bleeding-disorder"}],"wp:attachment":[{"href":"https:\/\/www.ehc.eu\/fr\/wp-json\/wp\/v2\/media?parent=5310"}],"wp:term":[{"taxonomy":"bleeding-disorder_cat","embeddable":true,"href":"https:\/\/www.ehc.eu\/fr\/wp-json\/wp\/v2\/bleeding-disorder_cat?post=5310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}